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KMID : 0385920090200010072
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Journal of the Korean Society of Emergency Medicine
2009 Volume.20 No. 1 p.72 ~ p.79
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The Serial Changes of the Serum Interleukin-6 and Interleukin-10 Concentrations in Patients who Received Therapeutic Hypothermia after Successful Cardiopulmonary Resuscitation
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Jeong Geon-Yeong
Yang Hyuk-Jun
Kim Jae-Kwang
Lee Mi-Jin
Kim Chung-Kwon
Lim Yong-Su
Kim Jin-Joo
Lee Hyyng-Seok
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Abstract
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Purpose: We wanted to investigate the serial changes of the serum interleukin-6 (IL-6) and interleukin-10 (IL-10) concentrations, according to the neurological outcome, in patients who received therapeutic hypothermia after successful
cardiopulmonary resuscitation. We also wanted to evaluate the usefulness of serum IL-6 and IL-10 as biochemical
markers to predict the neurological outcome.
Methods: We prospectively evaluated 23 patients who received therapeutic hypothermia after successful cardiopulmonary resuscitation. Blood samples were taken at 0, 4, 12, 24 and 48 hours after the return of spontaneous circulation. We compared the IL-6 and IL-10 levels between the good (CPC 1 to 2) and poor (CPC 3 to 5) neurological
outcome (NO) groups.
Results: The serum IL-6 level at 0 hr was significantly higher in the good NO group than that in the poor NO group. The periods of time that showed the greatest pattern of change between the good and poor NO groups were 4-12
hr for the IL-6 level and 0-4 hr for the IL-10 level. On the analysis of the ROC curve, the cut-off value for delta IL-10
(0-4 hr) was -5.4 pg/ml (AUC=0.827, sensitivity 80.0%, specificity 93.3%, p=0.032) and the cut-off value for delta
IL-6 (4-12 hr) was 62.8 ng/ml (AUC=0.527, sensitivity 80.0%, specificity 34.0%, p=0.861, respectively).
Conclusion: Our study suggests that the early delta IL-10 can be used as a neurological prognostic marker for
patients who are undergoing therapeutic hypothermia after successful cardiopulmonary resuscitation.
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KEYWORD
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Interleukin-6, Interleukin-10, Cardiac arrest, Hypothermia
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